Tip
Do not let Nocturne close in while kiting him. Be careful of Paranoia(R) after he reaches level 6. Break the tether on Unspeakable Horror (E) quickly.
Karthus vs Nocturne

Do not let Nocturne close in while kiting him. Be careful of Paranoia(R) after he reaches level 6. Break the tether on Unspeakable Horror (E) quickly.